Journal article
Behavioural state differentially engages septohippocampal cholinergic and GABAergic neurons in R6/1 Huntington's disease mice
MI Ransome, AJ Hannan
Neurobiology of Learning and Memory | Published : 2012
Abstract
Huntington's disease (HD) is a neurodegenerative condition characterised by progressive motor, psychological and cognitive decline. R6/1 HD transgenic mice model the clinical hippocampal-dependent cognitive deficits observed in patients. Cholinergic and GABAergic septohippocampal projections play important roles in hippocampal-dependent cognition. The current study examined neuronal activity of cholinergic and GABAergic septohippocampal projections in response to arousal elicited during differing behavioural states. The different behavioural states examined were; home cage (controls), acute exploration of a novel enriched environment and either spontaneous wakefulness (dark phase) or spontan..
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Awarded by Australian Research Council
Funding Acknowledgements
National Health and Medical Research Council Australia Grant Number: 509031(AJH). MIR is supported by a National Health and Medical Research Council Australian Biomedical Fellowship (ID628868) and AJH is supported by an Australian Research Council Future Fellowship. The authors state that the funding bodies played no role in any aspect of the study or the decision to publish it.